#Dissolution Calculation Software plus

An advantage of fiber-optics systems is the elimination of the need for these calculation corrections. Generally speaking, with sample withdrawal volumes of about 15 mL or less, difference between corrected and non-corrected results is about 1%. All instruments are compliant to regulations from. But if filtration occurs immediately at the media/sampling probe interface, the aliquot should only contain dissolved drug, which can be quantitated, and then the correction factor should be valid.ДЄdditionally, because we do not usually perform media replacement, the calculations also account for the decreased vessel volume after each sample aliquot is removed. The system is controlled by the 21 CFR Part 11 compliant User friendly WinDiss ARGUS dissolution software.

If your sampling procedure is such that aliquots are first collected (e.g., into a syringe barrel or through tubing) and then that aliquot is filtered, this correction factor will be deficient in that it can only determine the amount of dissolved drug in the sample aliquots, and cannot account for any undissolved drug in the withdrawn sample. Admittedly, the amounts contained in the withdrawn aliquots are likely small, but could contribute perhaps 1-2% of the final result.

#Dissolution Calculation Software plus

That is, the total amount of drug dissolved at each timepoint equals the amount of drug dissolved in the vessel plus the amounts withdrawn in the previous sample aliquots. Also keep in mind that there is a loss of entropy associated with the. All these factors increase the entropy of the solute.

One molecule is transformed into three ions. Yes, our calculations include a correction for the amount of drug removed at each of the timepoints. Consider, the dissolution of sodium sulfate, Na 2 SO 4 (s) > 2 Na + (aq) + SO 4 2-(aq) The entropy is increasing for two reasons here: A solid is formed into aqueous media.